Huntington s Disease ( Hd ) - 931 Words

Huntington s disease (HD) is basically neurological disorder that is triggered by a genetic mutation in the IT15 gene. Major characteristics of this disease are cognitive motor, psychiatric functions and advanced cell death in cortex and striatum. Certain important insights have emerged from the animal models that are related to the disease pathology and results of therapeutic strategies. A number of research studies have been conducted up till now and the majority of which have focused upon the use of toxin-induced models while studying the cell death, excitotoxicity and mitochondrial impairment. All of such models are based upon the quinolinic acid and 3-nitropropionic acid respectively. The huntingtin mutation was discovered in 1993 and this finding became the basis of newer models where similar genetic defect is incorporated in these newer models. It has been reported by Pouladi (2013) that the major reason behind the development of such animal models is revealing of causative ge ne in HD (Huntington s disease). The models that incorporate knock-in and transgenic rodents are true representative of pathology and HD progression. Advanced research has proved that production of genetic models in such species is really a difficult task, and in order to encrypt the gene mutation in specified brain areas, a more advanced model that can incorporate the viral vector can be an effective approach. HD is only one of a few trinucleotide rehash disarranges which are initiated by theShow MoreRelatedHuntington s Disease ( Hd )1250 Words   |  5 PagesStatement of Topic Huntington’s Disease (HD) is a genetic disorder in which the necrosis of cells in the brain causes early death [9]. The neurodegeneration of the brain leads to mechanical and psychological symptoms, which can present normally from 30 to 50 years of age or even earlier, which is referred to as Juvenile Huntington’s Disease [3,5,6]. Some mechanical symptoms of HD are change in gait, uncontrolled or sudden movement, abnormal face movement, turning the whole head instead of usingRead MoreHuntington s Disease ( Hd ) Essay764 Words   |  4 PagesHuntington’s disease (HD) is a late-onset, usually between 35 and 50 years old, neurodegenerative disorder prevalent in 3-7 per 100,000 people of European ancestry1. The disease, inherited in an autosomal dominant pattern2, is characterized by motor disturbance, intellectual decline, and psychiatric manifestations3. The disease is difficult to detect at an early stage of an individual’s life since its symptoms appear in the third to fifth decade of life. To better understand the disease, investigationsRead MoreHuntington s Disease ( Hd ) Is A Neurodegenerative Disease1289 Words   |  6 PagesHuntington’s disease (HD) is a neurodegenerative disease that affects roughly 10 individuals per 100,000 (Nopoulus, 2016). This disorder is normally associated with symptoms including motor impairment, namely slowed movements and random muscle contractions, as well as depression and cognitive dysfunction. However, another prominent symptom that has yet to be mentioned until recently is sleep disturbance and alteration of normal circadian rhythms. It is estimated that 60-90% of HD patients have sleepRead MoreGenetic Disease Is An Autosomal Dominant Neurodegenerative Disorder737 Words   |  3 PagesGenetic diseases are diseases that are passed on from parents to their offspring. An example of a genetic disease which can be inherited is Huntington Disease. Huntington Disease is an autosomal dominant neurodegenerative disorder with midlife onset characterised by psychiatric, cognitive and motor symptoms(G. Vonsattel and DiFiglia, 1998). The statistics for HD blah blah blah Like all genetic diseases, huntington s disease has a specific inheritance pattern. Huntington disease is an autosomalRead MoreHuntington s Disease : A Progressive Brain Disorder Caused By A Defective Gene1134 Words   |  5 PagesHuntington s Disease (HD) is a progressive brain disorder caused by a defective gene. This disease causes changes in the central area of the brain, which affect movement, mood and thinking skills. Nerve cells become impaired, causing several segments of the brain to fail. The disease disturbs movement, behavior and perception the affected people abilities to walk, think, reason and talk are slowly weakened to a point that they eventually become entirely dependent on other people for care. HD isRead MoreHuntington s Disease : A Dynamic, Neurological Disorder1632 Words   |  7 PagesHuntington s disease is a dynamic, neurological disorder. Tragically, it doesn t demonstrate manifestations until people have reached they’re 30 s or more. Children whose parent s have this genetic disorder have a 50-50 ( ) possibility of acquiring t he trait. History Huntington s disease was found by numerous researchers before George Huntington. For instance in the 1840 s HD was described in writing as a Chronic hereditary chorea by Dr Waters of Franklin N.Y., ( ) who found aRead MoreSymptoms And Treatment Of Huntington s Disease1350 Words   |  6 PagesHuntington s Disease Huntington s disease is an inherited neurodegenerative disease that is caused by a mutation on the HTT gene. It typically effects persons in their third to fifth decade of life and can be passed onto their children. Neurons in the brain waste away or degenerate in different areas causing the characterizing symptoms, such as dance-like movements and mental decline. Diagnosis and prognosis can be devastating to both individual and family. However, there are genetic tests thatRead MoreGenetic Testing And Mental Health Disorders1039 Words   |  5 PagesHuntington’s disease through human genome and family research. Diagnostic and presymptomatic testing is available by discovering a gene mutation for Huntington Disease (HD) and prepares persons who are at risk for Huntington Disease (HD) to ask for genetic testing. A multi-visit protocol is enacted when HD genetic testing is offered through HD testing centers, followed by education and counseling for those requesting to have HD gene testing. I will use this paper to define Huntington’s disease, choreaRead MoreHuntington s Disease And Its Effects831 Words   |  4 PagesHuntington’s Disease Huntington’s is named after George Huntington who was the first person to describe the disease in 1872. However it wasn’t until 1993 that the gene that causes Huntington’s was discovered. Huntington’s is an inherited progressive disease that affects the brain and causes severe cognitive decline. The result is involuntary movements, emotional disturbance, damaged perception and memory as well as overall lowered though processing ability. We know that Huntington’s is a geneticRead MoreResearch Paper on Huntingtons Disease1268 Words   |  6 PagesHuntington’s disease is a hereditary brain disorder that is progressive in neurodegeneration; which means, there is a loss of function and structures of one’s neurons. In the long run it results in the loss of both mental and physical control. The disease affects muscle coordination, cognition and behavior. It used to be known as Huntington’s chorea because it is the most common genetic disease that is the cause of abnormal twitching. Huntington s has an intense effect on patients, as individuals